Warning: require_once(inc/Autoload.php) [function.require-once]: failed to open stream: No such file or directory in C:\inetpub\onquestroot\index.php on line 12

Fatal error: require_once() [function.require]: Failed opening required 'inc/Autoload.php' (include_path='.;C:\php5\pear') in C:\inetpub\onquestroot\index.php on line 12